Product Description
4-[[(2,2,2-trifluoroacetyl)amino]methyl]benzoic acid、130029-61-7
AI Product Description
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4-[[(2,2,2-Trifluoroacetyl)amino]methyl]benzoic acid is a specialized organic compound widely utilized in the fields of medicinal chemistry and materials science. With the molecular formula C10H8F3NO3 and the CAS registry number 126753-98-2, this molecule serves as a critical building block for the synthesis of complex pharmaceutical agents and functional polymers. Its structure features a benzoic acid moiety linked via a methylene bridge to an amino group, which is further protected by a trifluoroacetyl (TFA) protecting group. The presence of the highly electronegative trifluoromethyl group significantly enhances the lipophilicity and metabolic stability of derivatives formed from this precursor, making it particularly valuable in drug discovery programs aimed at optimizing pharmacokinetic profiles.
In practical applications, this compound is primarily employed as a key intermediate in the preparation of bioactive molecules, including non-steroidal anti-inflammatory drugs (NSAIDs), kinase inhibitors, and other therapeutic candidates targeting various diseases. The TFA group acts as a robust protecting agent for the amine functionality during multi-step synthetic sequences, preventing unwanted side reactions while allowing for selective transformations elsewhere on the molecule. Once the desired structural modifications are complete, the trifluoroacetyl group can be easily removed under mild acidic or basic conditions to reveal the free amine, facilitating the final stages of drug development. Furthermore, due to its unique electronic properties, this chemical is increasingly explored in the design of advanced materials, such as liquid crystals and fluorinated polymers, where specific intermolecular interactions are required for performance enhancement. Researchers appreciate its high purity and reactivity, which streamline laboratory workflows and improve overall yield in large-scale production environments. As the demand for fluorinated compounds grows across the pharmaceutical and agrochemical industries, 4-[[(2,2,2-trifluoroacetyl)amino]methyl]benzoic acid remains an essential reagent for chemists seeking to innovate and develop next-generation solutions with superior efficacy and safety profiles.