The inner layer of the 20L reactor with 10 collection bottles can be put into the reaction solvent to do stirring reaction, and the 2 sets of interlayers can be connected to different cold and hot sources (freezing liquid, hot water or hot oil) to do circulating heating or cooling reaction. Under the set constant temperature conditions, in the closed glass reactor, stirring reaction can be carried out under normal or negative pressure conditions according to the use requirements, and can do the reflux and distillation of the reaction solution, which is an ideal pilot test and production equipment for modern fine chemical industry, biopharmaceutical and new material synthesis.