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Other Specialized Reagents

2-Fluoro-4-iodopyridine

Category:

Other Specialized Reagents

CAS NO:

22282-70-8

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

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Capot Chemical Co., Ltd.

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Basic Info

CAS Number

22282-70-8

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

2-Fluoro-4-iodopyridine、22282-70-8

AI Product Description

*The following content is generated by AI and is for reference only.

2-Fluoro-4-iodopyridine is a specialized heterocyclic building block widely utilized in modern organic synthesis and medicinal chemistry. With the chemical formula C5H3FIN and the CAS Registry Number 179896-04-1, this compound features a pyridine ring substituted with both a fluorine atom at the second position and an iodine atom at the fourth position. The presence of these two distinct halogen substituents grants the molecule unique reactivity profiles, making it an invaluable precursor for constructing complex pharmaceutical agents and functional materials. The primary utility of 2-fluoro-4-iodopyridine lies in its dual functionality as a substrate for cross-coupling reactions. The carbon-iodine bond is highly reactive under palladium or copper catalysis, facilitating efficient Suzuki-Miyaura, Heck, Stille, and Sonogashira couplings. This allows chemists to easily introduce diverse aryl or alkynyl groups at the 4-position without affecting the fluorine substituent. Conversely, the carbon-fluorine bond offers a handle for nucleophilic aromatic substitution (SnAr) under specific conditions, enabling further diversification at the 2-position. This orthogonal reactivity is crucial for the rapid assembly of library compounds during drug discovery campaigns. In the pharmaceutical industry, this intermediate serves as a key scaffold for synthesizing kinase inhibitors, antiviral agents, and other bioactive molecules where precise spatial arrangement of halogens enhances binding affinity and metabolic stability. The electron-withdrawing nature of the fluorine atom also modulates the electronic properties of the pyridine ring, influencing the basicity and solubility of the final products. Furthermore, researchers employ this compound in the development of advanced materials, including organic light-emitting diodes (OLEDs) and conductive polymers, where the rigid heterocyclic core contributes to thermal stability and charge transport characteristics. Due to its high purity requirements for such applications, commercial batches are typically supplied as off-white to pale yellow crystalline solids. Handling requires standard safety precautions due to potential toxicity, though it remains stable under ambient conditions when stored properly. Overall, 2-fluoro-4-iodopyridine represents a versatile tool for advancing synthetic methodologies and accelerating the development of next-generation therapeutic candidates.