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Other Specialized Reagents

2-Bromo-3,4-dimethoxypyridine

Category:

Other Specialized Reagents

CAS NO:

104819-52-5

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

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Capot Chemical Co., Ltd.

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Basic Info

CAS Number

104819-52-5

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

2-Bromo-3,4-dimethoxypyridine、104819-52-5

AI Product Description

*The following content is generated by AI and is for reference only.

2-Bromo-3,4-dimethoxypyridine is a specialized heterocyclic intermediate widely utilized in modern medicinal chemistry and organic synthesis. With the molecular formula C7H8BrNO2 and a CAS registry number of 100569-84-4, this compound features a pyridine ring substituted with two methoxy groups at the 3 and 4 positions and a bromine atom at the 2 position. This specific substitution pattern renders the molecule highly reactive toward palladium-catalyzed cross-coupling reactions, making it an indispensable building block for constructing complex pharmaceutical scaffolds. The primary application of 2-Bromo-3,4-dimethoxypyridine lies in its role as a key precursor for synthesizing biologically active compounds. Researchers frequently employ it to generate diverse pyridine derivatives through Suzuki-Miyaura, Heck, or Sonogashira couplings. These transformations allow chemists to introduce various functional groups, such as aryl, vinyl, or alkynyl moieties, onto the pyridine core. The resulting structures often exhibit significant therapeutic potential, including anti-inflammatory, antimicrobial, and anticancer activities. Consequently, this reagent is extensively used in the discovery and optimization of new drug candidates within the agrochemical and pharmaceutical industries. Beyond direct drug synthesis, the compound serves as a valuable model substrate for studying reaction mechanisms and developing novel catalytic systems. Its electron-deficient nature, influenced by the nitrogen atom in the ring and the electron-withdrawing bromine, facilitates nucleophilic aromatic substitution under specific conditions, offering synthetic versatility that simple halopyridines lack. Furthermore, the presence of the dimethoxy group can influence the physicochemical properties of final products, potentially enhancing metabolic stability or bioavailability in biological assays. Handling this substance requires standard laboratory safety precautions due to the potential irritant nature of brominated organic compounds. It is typically stored in a cool, dry place away from strong oxidizers and moisture. As global demand for innovative small-molecule therapeutics continues to rise, the strategic utility of 2-Bromo-3,4-dimethoxypyridine remains paramount in accelerating the pipeline from lead identification to clinical development, supporting the creation of next-generation medicines with improved efficacy profiles.