(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R,3R)-2,3-dihydroxybutanedioate is an important intermediate for Ticagrelor.
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<h3>Overview</h3>
<p><strong>(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R,3R)-2,3-dihydroxybutanedioate</strong> is a chiral salt intermediate primarily synthesized via asymmetric hydrogenation or resolution of racemic cyclopropylamines. This pharmaceutical building block features the molecular formula C<sub>11</sub>H<sub>12</sub>F<sub>2</sub>N<sub>2</sub>O<sub>6</sub>. While specific CAS numbers vary by supplier for the salt form, it serves as a critical precursor in modern medicinal chemistry.</p>
<h3>Application</h3>
<ul>
<li>Synthesis of antiviral agents targeting RNA polymerase.</li>
<li>Development of novel kinase inhibitors for oncology research.</li>
<li>Production of chiral ligands for asymmetric catalysis.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at 2-8°C to prevent hydrolysis. Handle with appropriate PPE due to potential sensitization risks. Ensure strict compliance with GMP standards during clinical drug manufacturing processes.</p>