FinancialNewsMedia.com News Commentary - Recently, scientific reports have shown that a universal coronavirus vaccine that protects against COVID-19 causing SARS-CoV-2, as well as other coronaviruses such as those causing SARS and MERS, produced promising results in a mouse study. Multiple SARS-CoV-2 vaccines have gone from development to distribution in many parts of the world, in record time. Indeed, in New York City, over 50% of the adult population has been vaccinated. But the emergence of SARS (in 2003) and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against the broader Sarbecovirussubgenus. According to a report from ClinicalOMICs said that: "Now, scientists at the University of North Carolina (UNC) Gillings School of Global Public Health are working to develop a vaccine that protects mice against not only SARS-CoV-2, including the emerging variants, but other coronaviruses as well. This research is published in the journal Science... To prevent a future coronavirus pandemic, the UNC-Chapel Hill researchers designed a vaccine to provide protection from the current SARS-CoV-2 coronavirus and a group of coronaviruses known to make the jump from animals to humans." Active biotech companies in the market this week include BioVaxys Technology Corp. (OTCQB: BVAXF) (CSE: BIOV), Moderna, Inc. (NASDAQ: MRNA), Sorrento Therapeutics, Inc. (NASDAQ: SRNE), Dynavax Technologies Corporation (NASDAQ: DVAX), INOVIO (NASDAQ: INO).
ClinicalOMICs continued: "The chimeric spike mRNAs induced high levels of broadly protective neutralizing antibodies against high-risk Sarbecoviruses. This result is in contrast to vaccinating using the mRNA from SARS-CoV-2 alone, which showed a marked reduction in neutralizing titers against heterologous Sarbecoviruses. In addition, a challenge with SARS-CoV and WIV-1 in mice that had been vaccinated with SARS-CoV-2 mRNA alone resulted in breakthrough infections. However, the chimeric spike mRNA vaccines used in this new study, "efficiently neutralized D614G, mink cluster five, and the UK B.1.1.7., and South African B.1.351 variants of concern. The authors write that the multiplexed-chimeric spikes can prevent SARS-like zoonotic coronavirus infections with pandemic potential. "Our findings look bright for the future because they suggest we can design more universal pan coronavirus vaccines to proactively guard against viruses we know are at risk for emerging in humans," Martinez said. "With this strategy, perhaps we can prevent a SARS-CoV-3. "
BioVaxys Technology Corp. (OTCQB: BVAXF) (CSE: BIOV.CNQ) BREAKING NEWS: BioVaxys Files US Patent Application for Pan-Sarbecovirus Vaccine - BioVaxys Technology Corp. ("BioVaxys") announced today that it has filed with the United States Patent & Trademark Office ("USPTO") a provisional patent application for its haptenized viral antigen vaccine platform to elicit a broad cross-reactive immune response against most or all sarbecoviruses, the family of Coronaviruses that includes SARS-CoV-2, which causes Covid-19.
A recent study published in the New England Journal of Medicine ("NEJM") evaluated human volunteers who had natural immunity to SARS-Cov-1 (a coronavirus similar to SARS-CoV-2 but with higher mortality), which broke out in 2003 and is often referred to as the first global pandemic of the 21st century, and who were immunized against SARS-CoV-2 with a widely used mRNA vaccine. The result was surprising: the recipients had neutralizing antibody not only to SARS-CoV-1 and SARS-CoV-2, but also to eight other sarbecoviruses, including emerging zoonotic sarbecoviruses that may have future pandemic potential. This cross-reactivity was due to similarities in the S-spike protein. Sarbecoviruses, such as SARS-CoV-1 and SARS-CoV-2, all bind to the ACE2 receptor, which makes them highly transmissible.
Biovaxys intends to leverage its haptenized viral protein vaccine platform to induce immunity against all or most sarbecoviruses by immunizing people who have convalesced from a documented Covid-19 infection, or received a full cour...
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