I. Medicinal value of sodium bicarbonate
Sodium bicarbonate has been used clinically for over 200 years. Sodium carbonate was originally used as an antacid to neutralize excessive gastric acid. Sodium bicarbonate was included in the Chinese Pharmacopoeia back in 1953, as well as all subsequent editions. In addition, sodium bicarbonate is also recorded in the International Pharmacopoeia (Fourth Edition), United States Pharmacopoeia (USP 43), Japanese Pharmacopoeia (JP17), European Pharmacopoeia (EP10), British Pharmacopoeia (BP2021), Indian Pharmacopoeia (IP2018), etc.
As to medicinal value, sodium bicarbonate has been proved to be useful for treatment of status asthmaticus, asthmatic pneumonia (bronchiolitis), acute myocardial infarction, cardiopulmonary resuscitation, cerebral thrombosis, thromboangiitis obliterans, vascular headache, vertigo, 8th cranial nerve damage caused by aminoglycoside antibiotics, epidemic hemorrhagic fever shock, lumbar disc herniation, organophosphorus pesticide poisoning, antipyretic, chronic nephritis, mycotic enteritis, influenza and many other diseases. It can also be used to wash tuberculous abscess, or as cardiac acoustic contrast agent. The intravenous administration of it can be used for toxic shock due to infection.
What is worth mentioning is that sodium bicarbonate is one of the earliest varieties included in the essential drug list in China. Among the Catalogue of Drugs for Basic National Medical Insurance of China, there are four antacids and Class A gastric mucosa protection drugs, including sodium bicarbonate and rhubarb sodium bicarbonate, all of which are oral regular release dosage forms. These two drugs are mainly used to treat hyperacidity, alkalized urine, indigestion, metabolic acidemia and fungal vaginitis, as well as shocks with acidosis symptoms caused by hyperkalemia and others.
There are many kinds of sodium bicarbonate preparations on the market at present, including tablet, capsule, granules, pulvis, compound preparation, injection, etc. The kinds with more production approval numbers include sodium bicarbonate tablets, sodium bicarbonate injections, rhubarb and sodium bicarbonate tablets, gentian and sodium bicarbonate tablets, compound gentian and sodium bicarbonate tablets, etc.
II. Supply and demand status of sodium bicarbonate
China started the industrial production of sodium bicarbonate in Liaoning, Sichuan and other places as early as the 1930s. The output of sodium bicarbonate in China continued to rise after the Reform and Opening Up, and with the situation of production and sales getting better, the production capacity and output surge to new highs again and again. The production capacity of sodium bicarbonate in China in 2008 ranked the first in the world, reaching over 18 million tons.
According to data, with the high-speed economic development, the consumption of sodium bicarbonate in China, Southeast Asia, India and other regions keeps rising, and these regions has become the main consumer market in the world.
As for the pharmaceutical market, there are many kinds of sodium bicarbonate dosage forms commercially available in China, including tablet, capsule, granule, pulvis, compound preparation, injection, etc. As for tablets, there are rhubarb and sodium bicarbonate tablets, compound sodium bicarbonate tablets, gentian and sodium bicarbonate tablets, bismuth, magnesium and sodium bicarbonate tablets, compound gentian and sodium bicarbonate tablets, pediatric rhei and sodium bicarbonate tablets, etc.
When it comes to the demand, let's take uremia as an example. There are more than 520,000 hemodialysis patients in China in 2017 and 620,000 in 2018. It is estimated that the current number of uremia patients in China will be more than 740,000. According to data, the total consumption of sodium bicarbonate products for injection and hemodialysis in recent years in China is about 80,000 tons, while its own output is around 60,000 tons. It is expected that by 2025, the demand for medicinal sodium bicarbonate in China will reach 100,000 tons.
Therefore, the medical demand for sodium bicarbonate in China is huge. If you are looking for different Read More
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