Recently, Viva Biotech's portfolio companies have new updates: TechnoDerma, VivaVision, Arthrosi, Apeiron Therapeutics and AceLink made solid progress in R&D; Full Circles published breakthrough results; Antag successfully completed financing.
TechnoDerma Medicines Completes U.S. Positive Ph2a Proof-of-Concept Trial with TopicalTDM-180935 Ointment for Atopic Dermatitis
On 6 January 2025, TechnoDerma Medicines, Inc. ("TechnoDerma Medicines"), a clinical-stage biopharmaceutical company which is invested and incubated by Viva BioInnovator (VBI), reported that the Company has completed its Phase 2a clinical trial (NCT06363461) of topical TDM-180935 ointment in patients with Atopic Dermatitis (AD).
Results show that the treatment was well-tolerated and demonstrated strong efficacy. Only minimal systemic exposure was evident and, thus, will enable future application to large body surface areas often seen in AD. These positive results provide support for continued advancement of the Atopic Dermatitis program.
VivaVision's VVN461 (non-steroidal eye drop) Achieves Primary Endpoint in Phase II Clinical Trial for Non-infectious Anterior Uveitis in Chinaand Reports Positive Topline Results from U.S. Phase 2 Trial for Post-Operative Inflammation Following Cataract Surgery
On January 3, 2025, VivaVision Biotech ("VivaVision"), invested and incubated by VBI, a clinical-stage, privately held biotechnology company focused on developing treatments for ocular diseases, announced that VVN461 achieves clinical endpoints in Phase II clinical trial for non-infectious anterior uveitis in China.
VVN461 is a first-in-class non-steroidal dual JAK1/TYK2 immunomodulator independently developed by VivaVision. In this clinical trial, it demonstrated excellent anti-inflammatory effects, with both dosage groups achieving statistical significance for non-inferiority compared to the positive control, 1% prednisolone acetate eye drops, in both primary and secondary efficacy endpoints.
Previously, on December 3, 2024, VivaVision announced positive topline results from its U.S. Phase 2 clinical trial of VVN461-CS-201, a potent non-steroidal dual JAK1/TYK2 immunomodulator for the treatment of post-operative inflammation following cataract surgery. VVN461 demonstrated statistical and clinical improvements across primary and many secondary endpoints compared to vehicle.
Arthrosi Therapeutics Surpasses 50% Patient Enrollment in Pivotal Phase 3 REDUCE 2 Trial of AR882 in Patients with Gout, Including Those with Tophaceous Gout
San Diego, California, USA – On December 18, 2024, Arthrosi Therapeutics, Inc. ("Arthrosi") invested and incubated by VBI, is a late-stage biotechnology company developing potentially best-in-class, highly selective next generation URAT1 inhibitors to reduce serum urate levels, flares and tophi in patients with gout. The company announced that it has enrolled more than 50% of patients in its pivotal Phase 3 REDUCE 2 trial evaluating AR882 for the reduction of sUA in gout patients.
Full Circles Therapeutics Achieves Breakthrough in Non-Viral Immune Cell Engineering
Cambridge, Massachusetts – On December 12, 2024, Full Circles Therapeutics ("Full Circles"), a leader in next-generation cell and gene therapies and invested and incubated by VBI. Full Circles announced the publication of a groundbreaking study in Nature Biotechnology. The paper, titled "Efficient Non-Viral Immune Cell Engineering Using Circular Single-Stranded DNA-Mediated Genomic Integration," introduces a novel method for the precise, non-viral engineering of immune cells, which has the potential to enhance both the safety and efficacy of cellular therapies while reducing production costs. Full Circles' innovative approach overcomes these limitations by utilizing circular single-stranded DNA (cssDNA), enabling stable genomic integration without the risks associated with viral delivery systems.
Antag Therapeutics Announces €80 Million Series A Financing
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