As mentioned above, common problems associated with glass-lined vessels are mechanical and thermal shocks. These defects severely damage the vessel, and unless these defects are removed, the vessel cannot get into production. Small, simple steps can be effective in preventing these problems.
· The operators should be properly educated. They should be trained for the importance of glass-lined vessels in pharma production, satisfactory working requirements, and harmful impacts of miss-handling.
· The glass-lined vessel should be operated according to standard specifications. The upper and lower limits of product temperature should not exceed the manufacturer's recommendations. Similarly, pressure requirements should also follow the manufacturer's recommendation. Following this specification will keep the vessel in healthy condition, resulting in the vessel's long life.
· Proper ground levels should be maintained and used. This keeps the vessel in stable condition and prevents any mechanical damage.
Accessories for vessels
Glass-lined vessels are supplied with different types of accessories to facilitate vessel operation. These accessories of Glass lining equipment play a vital role in producing the product and are commonly used to monitor the whole production operation from start to finish. This is necessary to produce accurate results according to the required specification.
Secondly, regulatory bodies also require the pharma manufacturers to record process parameters and keep the records. Regulatory bodies specifically inspect the process records during the inspection and can object if proper recordings are not made.
Some common accessories used in the glass-lined vessel include the following.
Temperature
Temperature is a common parameter that is monitored in a glass-line vessel. Pharma product manufacturing requires specific temperature requirements, as some chemicals require a specific temperature to react to form the desired product. Temperature is also monitored to regulate the internal temperature of the vessel. This is necessary to prevent the vessel from thermal shock.
The temperature sensors should be removable from the port, so that calibration team can be easily perform the calibration. The length of the sensor, should be as deep as possible to accurately measure the solution temperature. The temperature sensor can be any type such as pt100. Both analog and digital type temperature sensors can be used.
Analogue type consists of a gauge with appropriately calibrated dials and readings, and can only be used for viewing. Digital types, shows temperature on LED, or LCD display. Digital types can also store temperature values for later recording.
Sampling Port
A sampling port is a vessel output port to take out a limited and calculated solution from the vessel. This is often required to take put sample to assess the manufacturing stage of the pharmaceutical product. A valve is also attached to the sampling port to control the solution flow, independent of the main valve.
Earthing Port
Some solutions tend to generate static electricity when they contact the metallic surface. The static electricity remains in the system and can become hazardous for man and machine. It can cause electrical shock to humans and damage the machine's electrical system.
To prevent the hazards of static charge, the metallic surface is grounded. This transfers the static charge to the ground potential without causing any damage. Since glass-lined vessels' internal surfaces are coated with glass, these vessels require a particular port to connect to the vessel's metallic surface. This port is then used to ground the whole vessel.
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